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Record - 1 of 5   [TOP]
Compound IDNVIC0013
Compound Structure
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InhibitorKIN1408
SMILESCOC1=CC2=C(C=C1)SC(=N2)NC(C3=CC=C(C=C3)OC(F)F)C4=C(C5=C(C=CC=N5)C=C4)O
PubChem ID 119081414
Drug Bank ID\N
ChemSpider ID57251290
TargetActivation of IRF3-dependent innate immune responses
Assay TypeCPE visual
Assay DescriptionTwo-way analysis of variance with Bonferroni posttests
Assay SourceLife Chemicals Inc. and Kineta, Inc.
Cell TypeVero E6 cells
IC50 (nM)0.0
EC50 (in nM)0.0
OutcomeDecrease in the number of infectious virus particles
Molecular Weight (in g/mol)479.50
H-bond Acceptor7
H-bond Donor2
No. of Rotatable Bonds7
LogP5.47
Topological Polar Surface Area (Å)104.74
PUBMED ID26676770
Referencehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810700/
Curator Email IDkanikatuteja@gmail.com

                  
Record - 2 of 5   [TOP]
Compound IDNVIC0017
Compound Structure
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InhibitorPyrazofurin
SMILESC(C1C(C(C(O1)C2=NNC(=C2O)C(=O)N)O)O)O
PubChem ID 135413551
Drug Bank ID\N
ChemSpider ID10570780
TargetReplication
Assay TypeCPE visual
Assay Description\N
Assay Source\N
Cell TypeVero E6 cells
IC50 (nM)0.0
EC50 (in nM)0.0
OutcomeInhibition of viral replication
Molecular Weight (in g/mol)259.22
H-bond Acceptor8
H-bond Donor6
No. of Rotatable Bonds3
LogP-1.60
Topological Polar Surface Area (Å)161.92
PUBMED ID16641448
Referencehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472238/
Curator Email IDkanikatuteja@gmail.com

                  
Record - 3 of 5   [TOP]
Compound IDNVIC0065
Compound Structure
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InhibitorRibavirin
SMILESC1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=O)N
PubChem ID 37542
Drug Bank IDDB00811
ChemSpider ID34439
TargetReplication
Assay TypeCPE visual
Assay Description\N
Assay Source\N
Cell TypeVero E6 cells
IC50 (nM)0.0
EC50 (in nM)0.0
OutcomeInhibition of viral replication
Molecular Weight (in g/mol)244.21
H-bond Acceptor7
H-bond Donor4
No. of Rotatable Bonds3
LogP-3.00
Topological Polar Surface Area (Å)143.72
PUBMED ID16641448
Referencehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472238/
Curator Email IDkanikatuteja@gmail.com

                  
Record - 4 of 5   [TOP]
Compound IDNVIC0085
Compound Structure
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InhibitorEICAR
SMILESC#CC1=C(N=CN1C2C(C(C(O2)CO)O)O)C(=O)N
PubChem ID 453180
Drug Bank ID\N
ChemSpider ID399153
TargetReplication
Assay TypeCPE visual
Assay Description\N
Assay Source\N
Cell TypeVero E6 cells
IC50 (nM)0.0
EC50 (in nM)0.0
OutcomeInhibition of viral replication
Molecular Weight (in g/mol)267.24
H-bond Acceptor7
H-bond Donor5
No. of Rotatable Bonds3
LogP-1.80
Topological Polar Surface Area (Å)130.83
PUBMED ID16641448
Referencehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472238/
Curator Email IDkanikatuteja@gmail.com

                  
Record - 5 of 5   [TOP]
Compound IDNVIC0110
Compound Structure
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Inhibitor6-Azauridine
SMILESC1=NN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O
PubChem ID 5901
Drug Bank ID\N
ChemSpider ID203593
TargetReplication
Assay TypeCPE visual
Assay Description\N
Assay Source\N
Cell TypeVero E6 cells
IC50 (nM)0.0
EC50 (in nM)0.0
OutcomeInhibition of viral replication
Molecular Weight (in g/mol)245.19
H-bond Acceptor8
H-bond Donor4
No. of Rotatable Bonds2
LogP-1.90
Topological Polar Surface Area (Å)131.69
PUBMED ID16641448
Referencehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472238/
Curator Email IDkanikatuteja@gmail.com