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NVIK FDA Drugs Similarity

Similarity with FDA Approved Small Molecule Drugs


Table: List of NVI's molecules showing similarity with FDA approved small molecule drugs

NVIC ID  FDA approved drug  Tanimoto coefficient  Drug Bank ID of FDA drug  Side effects from Drug Bank  Rat acute toxicity (LD50, mol/kg) from Drug Bank 
NVIC0012

Sucrose0.84DB02772Not Available1.0936
NVIC0015

Remdesivir1DB14761Data regarding overdoses of remdesivir are not readily available. Overdoses of other nucleoside analogs like acyclovir can be managed with symptomatic and supportive treatment.Not Available
NVIC0035

Phenythoin1DB00252Phenytoin toxicity most often affects the cardiovascular and nervous systems. The most common presentation of toxicity depends on the route of administration. Cardiovascular adverse effects are most commonly linked to intravenous phenytoin administration, whereas neurological adverse effects are more common with oral phenytoin administration.2.1567
NVIC0051

Caffeine1DB00201In the case of caffeine overdose, seizures may occur, as caffeine is a central nervous system stimulant. Symptoms of overdose may include nausea, vomiting, diarrhea, and gastrointestinal upset. Intoxication with caffeine is included in the World Health Organization’s International Classification of Diseases (ICD-10). Agitation, anxiety, restlessness, insomnia, tachycardia, tremors, tachycardia, psychomotor agitation, and, in some cases, death can occur, depending on the amount of caffeine consumed. Overdose is more likely to occur in individuals who do not consume caffeine regularly but consume energy drinks.2.9741
NVIC0052

Verapamil hydrochloride0.98DB00661As there is no antidote for verapamil overdosage, treatment is largely supportive. Symptoms of overdose are generally consistent with verapamil's adverse effect profile (i.e. hypotension, bradycardia, arrhythmia) but instances of non-cardiogenic pulmonary edema have been observed following ingestion of large overdoses (up to 9 grams).3.4137
NVIC0054

Chloroquine phosphate0.88DB00608Patients experiencing an overdose may present with headache, drowsiness, visual disturbances, nausea, vomiting, cardiovascular collapse, shock, convulsions, respiratory arrest, cardiac arrest, and hypokalemia. Overdose should be managed with symptomatic and supportive treatment which may include prompt emesis, gastric lavage, and activated charcoal.2.9547
NVIC0055

Quinacrine0.96DB01103Symptoms of overdose include seizures, hypotension, cardiac arrhythmias, and cardiovascular collapse.2.8888
NVIC0058

Doxorubicin hydrochloride0.99DB00997Doxorubicin hydrochloride treatment can increase the risk of secondary malignancies based on postmarketing reports. Doxorubicin hydrochloride was mutagenic in the in vitro Ames assay, and clastogenic in multiple in vitro assays (CHO cell, V79 hamster cell, human lymphoblast, and SCE assays) and the in vivo mouse micronucleus assay. Based on postmarketing reports, pediatric patients treated with doxorubicin hydrochloride are at risk for developing late cardiovascular dysfunction. Risk factors include young age at treatment (especially < 5 years), high cumulative doses and receipt of combined modality therapy. Long-term periodic cardiovascular monitoring is recommended for all pediatric patients who have received doxorubicin hydrochloride. Doxorubicin hydrochloride, as a component of intensive chemotherapy regimens administered to pediatric patients, may contribute to prepubertal growth failure and may also contribute to gonadal impairment, which is usually temporary.2.6644
NVIC0061

Gabapentin1DB00996Symptoms of overdose are consistent with the drug's adverse effect profile and involve CNS depression (e.g. dizziness, drowsiness, slurred speech, lethargy, loss of consciousness) and gastrointestinal symptoms such as diarrhea. Multi-drug overdoses involving gabapentin, particularly in combination with other CNS depressants such as opioids, can result in coma and death - this possibility should be considered when managing overdosage.1.6472
NVIC0062

Crystal violet0.96DB00406Oral administration can cause gastrointestinal irritation, and intravenous injection can cause depression in the white blood cell count.2.5102
NVIC0065

Ribavirin1DB00811Rivabirin and PEG-Interferon Alfa-2A dual therapy is associated with flu-like symptoms, depression, suicide, insomnia, irritability, relapse of drug abuse/overdose, hepatic decompensation in 2% of HIV co-infected patients and bacterial infections each occurring at a frequency of less than 1%. Ribavirin-induced anemia is a dose-dependent adverse effect where reduced hemoglobin levels can be seen within the first 1-2 weeks in therapy.1.9876
NVIC0066

Bortezomib1DB00188The symptoms from overdose included the acute onset of symptomatic hypotension and thrombocytopenia. As there is no known antidote for bortezomib overdosage, monitoring of vital signs and appropriate supportive care should be initiated when drug overdosage is suspected. In monkeys and dogs, increased heart rate, decreased contractility, hypotension, and death were observed with the intravenous dose as low as two times the recommended clinical dose on a mg/m2 basis. A case of a slight increase in the corrected QT interval leading to death occurred in dog studies.2.4537
NVIC0079

Linoleic acid0.88DB14104Not AvailableNot Available
NVIC0079

Oleic acid1DB04224Not Available1.3991
NVIC0083

Nisoldipine0.8DB00401Not Available2.6277
NVIC0083

Nifedipine1DB01115Patients experiencing an overdose may present with hypotension, sinus node dysfunction, atrioventricular node dysfunction, and reflex tachycardia.2.5425
NVIC0084

Tamoxifen0.9DB00675High doses of tamoxifen in animals lead to respiratory difficulty and convulsions. High doses in advanced metastatic cancer patients resulted in acute neurotoxicity seen by tremor, hyperreflexia, unsteady gait, and dizziness.1.9882
NVIC0090

Phenoxybenzamine HCl0.97DB00925Symptoms of overdose are largely the result of block of the sympathetic nervous system and of the circulating epinephrine. They may include postural hypotension resulting in dizziness or fainting, tachycardia, particularly postural, vomiting; lethargy, and shock.2.1163
NVIC0091

Praziquantel1DB01058Praziquantel had no effect on fertility and general reproductive performance of male and female rats when given at oral doses ranging from 30 to 300 mg/kg body weight (up to 0.65 times the human daily dose based on body surface area)2.0726
NVIC0093

Propranolol hydrochloride0.97DB00571Symptoms of overdose include hypotension, hypoglycemic seizure, restlessness, euphoria, insomnia. Patients with asthma may develop bronchospasm2.5625
NVIC0096

Cyclosporine1DB00091There are little data available in the literature regarding overdoses with cyclosporine, but hepatotoxicity and nephrotoxicity may occur. One case report of an cyclosporine overdose due to medical error was made involving a 26 year old female and noted the occurrence of nausea, flushing, tremor, vertigo and vomiting, which resolved within about 1 day. Anorexia and a feeling of increased body girth were also experienced by this patient and resolved within about 2 weeks.2.8788
NVIC0102

Bosutinib1DB06616Fetal exposure to bosutinib-derived radioactivity during pregnancy was demonstrated in a placental-transfer study in pregnant rats. Experience with bosutinib overdose in clinical studies was limited to isolated cases. There were no reports of any serious adverse events associated with the overdoses.2.4201
NVIC0111

Amlodipine besylate1DB00381An overdose of amlodipine could result in a high degree of peripheral vasodilatation with a possibility of reflex tachycardia. Significant and prolonged hypotension leading to shock and fatal outcomes have been reported2.5396
NVIC0117

Chloroquine phosphate1DB00608Patients experiencing an overdose may present with headache, drowsiness, visual disturbances, nausea, vomiting, cardiovascular collapse, shock, convulsions, respiratory arrest, cardiac arrest, and hypokalemia.2.9547
NVIC0118

Cholesterol0.8DB04540Not Available2.8078
NVIC0119

Lithium citrate0.89DB14507Not AvailableNot Available
NVIC0122

Dantrolene1DB01219Symptoms which may occur in case of overdose include, but are not limited to, muscular weakness and alterations in the state of consciousness (e.g., lethargy, coma), vomiting, diarrhea, and crystalluria.2.539
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