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Record - 1 of 2   [TOP]
Compound IDNVIC0074
Compound Structure
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Inhibitor7-(4-Carbamoylpiperidin-1-yl)-1-cyclopropyl-N-(2,4-dichlorobenzyl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxamide
SMILESC1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCC(CC4)C(=O)N)F)C(=O)NCC5=C(C=C(C=C5)Cl)Cl
PubChem ID 44191023
Drug Bank ID\N
ChemSpider ID24623404
Targetfusion glycoprotein (NiV-F)
Assay TypeCell-cell fusion assay
Assay DescriptionSize of the syncytia
Assay Sourcehttps://pubchem.ncbi.nlm.nih.gov/bioassay/420714#section=Source
Cell TypeVero cells
IC50 (nM)0.0
EC50 (in nM)1500.0
OutcomeInhibit NiV-induced virus-cell and cell-cell fusion
Molecular Weight (in g/mol)531.41
H-bond Acceptor10
H-bond Donor2
No. of Rotatable Bonds7
LogP4.02
Topological Polar Surface Area (Å)95.74
PUBMED ID19499921
Referencehttps://pubs.acs.org/doi/full/10.1021/jm900411s
Curator Email IDanshu@imtech.res.in

                  
Record - 2 of 2   [TOP]
Compound IDNVIC0078
Compound Structure
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InhibitorGS-441524 (Nuc)
SMILESC1=C2C(=NC=NN2C(=C1)C3(C(C(C(O3)CO)O)O)C#N)N
PubChem ID 44468216
Drug Bank IDDB15686
ChemSpider ID28499294
TargetRNA-dependent RNA polymerase (RdRp)
Assay TypeReporter assay
Assay DescriptionNon-linear regression analysis
Assay SourceGS-441524 (Nuc) were synthesized at Gilead Sciences, Inc.
Cell TypeHeLa and HEK293T/17 cell
IC50 (nM)0.0
EC50 (in nM)1500.0
OutcomeInhibition of transcription in NiV (Rec. M-Luc2AM)
Molecular Weight (in g/mol)291.27
H-bond Acceptor5
H-bond Donor4
No. of Rotatable Bonds2
LogP-2.00
Topological Polar Surface Area (Å)149.92
PUBMED ID28262699
Referencehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338263/
Curator Email IDpriyankapaul008@gmail.com