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Record - 1 of 3   [TOP]
Compound IDNVIC0017
Compound Structure
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InhibitorPyrazofurin
SMILESC(C1C(C(C(O1)C2=NNC(=C2O)C(=O)N)O)O)O
PubChem ID 135413551
Drug Bank ID\N
ChemSpider ID10570780
TargetOrotidine 5?-monophosphate decarboxylase
Assay TypeReporter assay
Assay Description\N
Assay SourceToronto Research Chemicals
Cell TypeHEK 293T cells
IC50 (nM)0.0
EC50 (in nM)432.0
OutcomeInhibition cellular of Pyrimidine biosynthesis
Molecular Weight (in g/mol)259.22
H-bond Acceptor8
H-bond Donor6
No. of Rotatable Bonds3
LogP-1.60
Topological Polar Surface Area (Å)161.92
PUBMED ID24680955
Referencehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100748/
Curator Email IDkanikatuteja@gmail.com

                  
Record - 2 of 3   [TOP]
Compound IDNVIC0017
Compound Structure
DOWNLOAD:
InhibitorPyrazofurin
SMILESC(C1C(C(C(O1)C2=NNC(=C2O)C(=O)N)O)O)O
PubChem ID 135413551
Drug Bank ID\N
ChemSpider ID10570780
TargetOrotidine 5?-monophosphate decarboxylase
Assay TypeReporter assay
Assay Description\N
Assay SourceToronto Research Chemicals
Cell TypeHEK 293T cells
IC50 (nM)0.0
EC50 (in nM)281.0
OutcomeInhibition cellular of Pyrimidine biosynthesis
Molecular Weight (in g/mol)259.22
H-bond Acceptor8
H-bond Donor6
No. of Rotatable Bonds3
LogP-1.60
Topological Polar Surface Area (Å)161.92
PUBMED ID24680955
Referencehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100748/
Curator Email IDkanikatuteja@gmail.com

                  
Record - 3 of 3   [TOP]
Compound IDNVIC0017
Compound Structure
DOWNLOAD:
InhibitorPyrazofurin
SMILESC(C1C(C(C(O1)C2=NNC(=C2O)C(=O)N)O)O)O
PubChem ID 135413551
Drug Bank ID\N
ChemSpider ID10570780
TargetReplication
Assay TypeCPE visual
Assay Description\N
Assay Source\N
Cell TypeVero E6 cells
IC50 (nM)0.0
EC50 (in nM)0.0
OutcomeInhibition of viral replication
Molecular Weight (in g/mol)259.22
H-bond Acceptor8
H-bond Donor6
No. of Rotatable Bonds3
LogP-1.60
Topological Polar Surface Area (Å)161.92
PUBMED ID16641448
Referencehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472238/
Curator Email IDkanikatuteja@gmail.com