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Record - 1 of 2   [TOP]
Compound IDNVIC0066
Compound Structure
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InhibitorBortezomib
SMILESB(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O
PubChem ID 387447
Drug Bank IDDB00188
ChemSpider ID343402
Targetmatrix protein (NiV-M)
Assay TypeCPE visual
Assay DescriptionVirus Titre Reduction assay
Assay SourceChemieTek
Cell TypeHeLa cells
IC50 (nM)2.7
EC50 (in nM)0.0
OutcomeInhibition of NiV infection.
Molecular Weight (in g/mol)384.24
H-bond Acceptor6
H-bond Donor4
No. of Rotatable Bonds11
LogP3.23
Topological Polar Surface Area (Å)124.44
PUBMED ID21085610
Referencehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978725/
Curator Email IDkanikatuteja@gmail.com

                  
Record - 2 of 2   [TOP]
Compound IDNVIC0088
Compound Structure
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InhibitorMG132
SMILESCC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1
PubChem ID 462382
Drug Bank ID\N
ChemSpider ID406728
Targetmatrix protein (NiV-M)
Assay TypeCPE visual
Assay DescriptionVirus Titre Reduction assay
Assay SourceCalbiochem
Cell TypeHeLa cells
IC50 (nM)0.5
EC50 (in nM)0.0
OutcomeReduction in viral titers
Molecular Weight (in g/mol)475.63
H-bond Acceptor8
H-bond Donor3
No. of Rotatable Bonds18
LogP6.81
Topological Polar Surface Area (Å)113.60
PUBMED ID21085610
Referencehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978725/
Curator Email IDkanikatuteja@gmail.com