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Compound IDNVIC0013
Compound Structure
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InhibitorKIN1408
SMILESCOC1=CC2=C(C=C1)SC(=N2)NC(C3=CC=C(C=C3)OC(F)F)C4=C(C5=C(C=CC=N5)C=C4)O
PubChem ID 119081414
Drug Bank ID\N
ChemSpider ID57251290
TargetActivation of IRF3-dependent innate immune responses
Assay TypeCPE visual
Assay DescriptionTwo-way analysis of variance with Bonferroni posttests
Assay SourceLife Chemicals Inc. and Kineta, Inc.
Cell TypeVero E6 cells
IC50 (nM)0.0
EC50 (in nM)0.0
OutcomeDecrease in the number of infectious virus particles
Molecular Weight (in g/mol)479.50
H-bond Acceptor7
H-bond Donor2
No. of Rotatable Bonds7
LogP5.47
Topological Polar Surface Area (Å)104.74
PUBMED ID26676770
Referencehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810700/
Curator Email IDkanikatuteja@gmail.com