NR-PTMkb

NUCLEAR RECEPTOR POST TRANSLATIONAL MODIFICATION KNOWLEDGEBASE

Query Builder

Hypothesis Generator (Query Builder)

Users may build complex queries using the logical operators 'AND' and 'OR'. Each sub-query can be built using other operators such as LIKE, NOT LIKE, while dealing with strings like words or letters. The Query builder aids to the flexibility of performing search on a number of fields simultaneously.




Sr.No.Uniprot IDOrganismUniprot ID IsoformsPTMDomainSourceModifierNuclear ReceptorSite of PTM (Uniprot)Effect
1 P10275 Human P10275-1 Phosphorylation N-terminal Domain Curated Src Protooncogene tyrosine-protein kinase AR Y225 Increase in AR tyrosine phosphorylation and Src kinase activity is associated with prostate cancer progression.
2 P10275 Human P10275-1 Phosphorylation N-terminal Domain Curated Src Protooncogene tyrosine-protein kinase AR Y309 Increase in AR tyrosine phosphorylation and Src kinase activity is associated with prostate cancer progression.
3 P10275 Human P10275-1 Phosphorylation N-terminal Domain Curated Src Protooncogene tyrosine-protein kinase AR Y348 Increase in AR tyrosine phosphorylation and Src kinase activity is associated with prostate cancer progression.
4 P10275 Human P10275-1 Phosphorylation N-terminal Domain Curated Src Protooncogene tyrosine-protein kinase AR Y364 Increase in AR tyrosine phosphorylation and Src kinase activity is associated with prostate cancer progression.
5 P10275 Human P10275-1 Phosphorylation N-terminal Domain Curated Src Protooncogene tyrosine-protein kinase AR Y395 Increase in AR tyrosine phosphorylation and Src kinase activity is associated with prostate cancer progression.
6 P10275 Human P10275-1 Phosphorylation N-terminal Domain Curated Src Protooncogene tyrosine-protein kinase AR Y552 Increase in AR tyrosine phosphorylation and Src kinase activity is associated with prostate cancer progression.
7 P10275 Human P10275-1 Phosphorylation N-terminal Domain Curated Src Protooncogene tyrosine-protein kinase AR Y535 Phosphorylation of Y534 may be required for the Src-promoted nuclear translocation of AR under androgen-depleted conditions and Src-induced ARY534 phosphorylation is important for prostate tumor growth under androgen-depleted conditions.
8 P41235 Human P41235-2 Phosphorylation N-terminal Domain Curated Src Protooncogene tyrosine-protein kinase HNF4ɑ Y23 pY14 binds the SH2 domain of Src and the proline-rich F domain of HNF4α binds the Src SH3 domain, thereby facilitating the phosphorylation of first Y277 and then Y279 in the HNF4α LBD. The net result is a triply phosphorylated HNF4α in which pY277 and pY279 evidently disrupt the coactivator binding site, resulting in a loss of transactivation, nuclear localization, and protein stability.
9 Q96RI1 Human Q96RI1-1 Phosphorylation N-terminal Domain Curated Src Protooncogene tyrosine-protein kinase FXR Y67 FXR is phosphorylated at Y67 by non-receptor tyrosine kinase; Src; in response to postprandial FGF19; which is critical for its nuclear localization and transcriptional regulation of BA levels.

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