CRAB_LOGO

A comprehensive repository of Acinetobacter baumannii to understand the molecular landscape of antimicrobial resistance

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Ab-AMR Statistics:

Table - 1: General information about Ab-AMR

S.No.	Ab-AMR Features	No. of entries
1	Resistance profile	788 genomes
3	Antibiogram (CLSI standards)	788 clinical isolates
4	Resistant determinanats	364 DR determinants
5	Essential genes	614 genes
6	Drug targets	81 genes
7	Pathways	1334 genes
7	Reactions	1211
8	PDB	221 structures
9	Transcription factors	118 genes
10	Sigma factors	4 genes
11	Two component system	14 genes

Table - 2: General information about Ab-AMR Resistant determinants

S.No.	Resistance mechanism	No. of associated genes
1	Antibiotic inactivation	273
I)	Beta-lactamases	232
II)	Aminoglycoside modification	30
III)	Chloramphenicol acetyltransferases (AACs)	4
2	Efflux pumps	46
3	Target modification	19
I)	Target replacement	10
II)	Target alteration	7
III)	Target protection	2
4	Other mechanisms	14
5	Permeability defects	12

Figure 1: Distribution of DR Determinants among reported resistance mechanisms

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Figure 2: ‘Ab-AMR’ architecture representing the specific feature of a bacterial genome annotation in context of understanding the entire molecular landscape of A. baumannii.

Figure 3: Frequency distribution graph of 788 clinical isolates.

Figure 4: Distribution of Beta-lactamase enzyme classes in Acinetobacter.

Figure 5: Commonly presecribing antibiotics for Acinetobacter baumannii with mechanism of action (the color antibiotics are corresponding to the color of bactericidal and bacteriostatic, dotted line color of antibiotic is associated with the corresponding mechanism of action and red color of antibiotics is the class of mentioned antibiotics)